2.4. Evidence review relevant to each theme was systematic review of the literature impractical due to funding and time constraints. The guide- line development an should be prioritised, and a Cochrane review was undertaken to examine the efficacy of antidepressants in people with physical illness and those needing palliative c 2021 For other aspects of the management of depression in palliative care, only the best existing evidence was identified: thus if strong evidence (e.g. from an RCTor meta-analysis) was avail- able to answer a specific question, weaker evidence (e.g. cross sectional surveys, case series) was not sought and appraised.