trans-chalcone (1,3-diphenyl-2-propene-1-one) is the simplest chalcone, i.e. the unsubstituted compound, which possesses several therapeutic properties: among other aspects it was successfully used in studies concerning the treatment of leishmaniasis [7], the prevention of the expression of the vascular endothelia growth factor (VEGF) and the retinal neovascularization in the ischemic retina [8].