This CPR developed a set of prognostic variables that may help identify women with TTH who are likely to experience clinically meaningful changes in self-perceived recovery following a single physical therapy session including both joint mobilization and muscle TrP therapy. Perhaps using these prognostic factors to classify TTH patients into subgroups prior to the carrying out of a randomized clinical trial might lead to increased effect sizes. However, it should be noted that this study is the first step in the process of identifying prognostic variables. Our study may helps assist daily neurological practice, as neurologists could use the predictors identified in the current CPR to refer patients to physical therapy. Nevertheless, future studies are necessary to validate
the predictive value of the prognostic factors in a randomized controlled trial with a comparison group and a long-term follow-up. Finally, if these variables do turn out to be useful guides to clinical decision making, an impact analysis to determine the effects on economic factors, clinical practice, and patient outcomes should be conducted.