Despite 20 years of reassuring research, many people still avoid caffeinated coffee because they worry about the biological effects of caffeine. What is the conclusion of so much attention? We have thought that coffee is good for your health when consumed in moderation.Harvard Women’s Health Watch (2004) reported that current research reveals that in moderation coffee is a safe beverage that may even offer some health benefits. However, it is also emphasized that difficulties and challenges in designing a solid experiment or clinical trials to elucidate the effects of coffee on human health are present.