There is epidemiological evidence for cardiovascular effects of ambient
ultrafine particulate matter (PM) [3]. Indications that inhaled particles can
translocate to the other organs [4] suggest a link between nanoparticles and neurodegenerative
diseases [5] and other systemic pathologies. Monitoring humanand soil), determining the rate of particle uptake by humans and food chain organisms,
and measuring the resulting nanoparticle concentrations in target organsare major challenges for nanoparticle toxicology studies [6].
Most nanoparticle uptake and translocation research has quantified nanoparticles
in vivo using some type of unique particle label. For example, nanoparticle
laboratory studies have included radioactive particles [4], trace metals such
as gold and iridium [7], and fluorescent particles [8]. However, the population
exposures most relevant to health involve the emissions or deliberate release of
high-production-volume manufactured nanomaterials and exposures to incidental
nanoparticles, such as soot. Combustion emissions and manufactured powders
such as fumed silica, ultrafine titanium dioxide (TiO2), and similar industrial
materials rarely have a unique and easily detected label.
There is epidemiological evidence for cardiovascular effects of ambientultrafine particulate matter (PM) [3]. Indications that inhaled particles cantranslocate to the other organs [4] suggest a link between nanoparticles and neurodegenerativediseases [5] and other systemic pathologies. Monitoring humanand soil), determining the rate of particle uptake by humans and food chain organisms,and measuring the resulting nanoparticle concentrations in target organsare major challenges for nanoparticle toxicology studies [6].Most nanoparticle uptake and translocation research has quantified nanoparticlesin vivo using some type of unique particle label. For example, nanoparticlelaboratory studies have included radioactive particles [4], trace metals suchas gold and iridium [7], and fluorescent particles [8]. However, the populationexposures most relevant to health involve the emissions or deliberate release ofhigh-production-volume manufactured nanomaterials and exposures to incidentalnanoparticles, such as soot. Combustion emissions and manufactured powderssuch as fumed silica, ultrafine titanium dioxide (TiO2), and similar industrialmaterials rarely have a unique and easily detected label.
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