Where evidence was absent or equivocal Delphi consensus methods were implemented to elicit and refine expert opinion. Evidence graded according to the process proposed by GRADE. The resulting guideline has three main prevention; (2) detection, diagnosis and assessment; and treatment. The prevention section outlines strategies such as optimal palliative care and support effective communication and information-giving. The detection section provides recom mendations on symptoms, screening, assessment. The treatment section gives guidance on treatment decisions including choice of psychological therapy and antidepressant medication. This is the first comprehensive, evidence-based guideline on managing depression in palliative care. It has the potential to improve patient outcomes by enabling clinicians to access and implement evidence-based knowledge quickly and easily