Diabetes is a serious health problem. Searching for alternative natural antioxidants is considered important
strategy to manage diabetes. This study evaluated the effect of Riceberry bran oil (RBBO) supplementation
on oxidative stress and organ histology in streptozotocin-induced diabetic rats fed a high fat (HF)
diet. Adult male Sprague-Dawley rats with hyperglycemia were divided into four groups: DM group fed a
HF diet alone; DMRL group fed a HF diet and 5% RBBO; DMRM group fed a HF diet and 7.5% RBBO; DMRH
group fed a HF diet and 15% RBBO. Normal rats were used as normal control and were divided into NC and
NR group fed a normal diet containing either 5% corn oil or 5% RBBO, respectively. After 12 weeks, RBBO
significantly decreased malondialdehyde and restored superoxide dismutase, catalase, glutathione peroxidase,
coenzyme Q10 and ORAC levels in diabetic rats. RBBO additionally improved the regenerative
changes of the pancreas, kidneys, heart and liver. These findings indicate that pigmented RBBO could provide
beneficial effect on diabetes by decreasing oxidative stress and recovering organ histology.
Diabetes is a serious health problem. Searching for alternative natural antioxidants is considered important
strategy to manage diabetes. This study evaluated the effect of Riceberry bran oil (RBBO) supplementation
on oxidative stress and organ histology in streptozotocin-induced diabetic rats fed a high fat (HF)
diet. Adult male Sprague-Dawley rats with hyperglycemia were divided into four groups: DM group fed a
HF diet alone; DMRL group fed a HF diet and 5% RBBO; DMRM group fed a HF diet and 7.5% RBBO; DMRH
group fed a HF diet and 15% RBBO. Normal rats were used as normal control and were divided into NC and
NR group fed a normal diet containing either 5% corn oil or 5% RBBO, respectively. After 12 weeks, RBBO
significantly decreased malondialdehyde and restored superoxide dismutase, catalase, glutathione peroxidase,
coenzyme Q10 and ORAC levels in diabetic rats. RBBO additionally improved the regenerative
changes of the pancreas, kidneys, heart and liver. These findings indicate that pigmented RBBO could provide
beneficial effect on diabetes by decreasing oxidative stress and recovering organ histology.
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