3. Theory/calculation
The majority of studies have reported higher levels of sE-selectin
in sepsis compared to healthy controls or other patient groups
without sepsis. Since E-selectin is exclusively expressed on activated
endothelial cells and no biomarker of endothelial activation/
dysfunction has so far been shown to provide consistent
clinical utility as either a diagnostic or prognostic indicator in sepsis,
we pursued the early patterns of sE-selectin, sP-selectin and
other endothelium-related molecules in critically-ill patients at
increased risk for infectious complications and organ failure. It
has been shown that early recognition of sepsis improves patients’
outcomes . The results of this study could help in facilitating
timely detection of sepsis risk in critically-ill patients.