Despite the vast size of the giant clam, giant clams are preyed upon by a number of marine predators, many of which are actually much smaller in size than the giant clam itself. Eels, snails, fish and starfish are all known to snack on small parts of the giant clam.
Giant clams are also preyed upon by humans, who catch the giant clams in order to feed on a particular muscle which is seen as a culinary delicacy in many countries. The excessive harvesting of giant clams by humans has led to rapid declines in the world's giant clam population.