Clinicians traditionally rely upon self-report to assess medication adherence. During the interview,the patient or occasionally the caregiver will be asked a direct question regarding medication use.Healthcare professionals often pose a single closed-ended, judgmental question such as, “Do you take your medicines as prescribed?” Invariably, patients respond ‘Yes’ for fear of alienating their provider and because of discomfort in sharing difficulties and because of discomfort in sharing difficulties associated with medication use. This direct method of questioning has been proven to be unreliable.An alternative interview approach provides more complete and reliable information. By posing open-ended, nonjudgmental questions, interviewers may actually encourage patients to share their experiences with medications. Phrases such as, “Will you tell me how you take your medications?”, have proven helpful in soliciting greater information.Elderly patients may also be asked to show the interviewer how they take their medications.This method allows the interviewer to assess the number of tablets or pills taken, the time of day the medication is taken, and the indication for use of each medicine. Table III lists several questions which may be useful when inquiring about medication use.