Although consumer research indicates that heart health is the main health concern, sales of digestive health products are by far stronger and outsell heart health products. Due to its essential function, the heart is well protected, and the impact that ingested materials can have on the heart is typically limited. However, many indirect factors exist which negatively affect the heart, and we are now learning that the digestive microbiota profile can define health in nearly all the organs of the body, including the heart. This chapter will discuss these direct and indirect factors and how probiotics can possibly improve cardiac health.