In conclusion, the expression level of miR-1246 was increased in OSCC tissues and cell lines and it was correlated with TNM stage, nodal status, and tumor grade. In addition, high miR-1246 expression was associated with poorer survival and served as an independent prognostic factor in patients with OSCC, suggesting that miR-1246 may be a promising prognostic biomarker for OSCC. However, the relatively small sample of this study is a limitation; a larger sample size would definitely be desirable with longer follow-up to firmly establish the diagnostic value of miR-1246 in OSCC. In addition, further studies are needed to elucidate the role of miR-1246 in OSCC at the cellular level