The magnitude of observed BP reduction seems to beclinically relevant. ABPM measurements allow a fullevaluation of BP homeostasis and are more predictive ofcardiovascular events than offi ce-based BP.15Indeed, wehave demonstrated in a cross-sectional study in patientswith type 2 diabetes that systolic BP was the ABPMparameter mostly associated with echocardiographicleft ventricular structural abnormalities and albumin-uria.28Furthermore, every 10-mm Hg reduction insystolic BP was associated with a decrease of 13% inmicrovascular chronic diabetic complications and of12% in fatal and nonfatal myocardial infarction.1Moreover, in our trial more than half of the patientsin the intervention group reached the recommendedgoals for daytime ABPM.6,20,29Therefore, it should alsobe taken into account that lifestyle intervention was notassociated with common side effects presented byantihypertensive drugs