Serendipitously, the same group also discovered that the compound
AL18 (22), previously reported as a potent inhibitor of human
cytomegalovirus DNA polymerase87, blocks the PA/PB1 interaction
and inhibits influenza A virus replication88. In another study, Fukuoka
and coworkers89 performed a docking simulation-based screening of
4000 drugs. Benzbromarone, diclazuril, and trenbolone acetate, were
identified as three successful hit compounds with strong anti-influenza
activities (Fig. 5). Two compounds, benzbromarone and diclazuril,