Adenosine plays an important role in biochemical processes such as energy transfer. It is a brain endogenous anticonvulsant that is considered to be responsible for seizures arrest and postictal refractoriness. Adenosine and its analogues can suppress pharmacoresistant seizures but most of these pharmacological approaches are limited to strong systemic side effects so activation of central adenosine
A1 receptors leads to the suppression of seizure activity in mouse model of drug resistant epilepsy.40