2015 Evidence Summary
One trial113 assessed short-term and longer-term outcomes when comparing standard-dose epinephrine to placebo.
Standard-dose epinephrine was defined as 1 mg given IV/ IO every 3 to 5 minutes. For both survival to discharge and survival to discharge with good neurologic outcome, there was no benefit with standard-dose epinephrine; however, the study was stopped early and was therefore underpowered for analysis of either of these outcomes (enrolled approxi- mately 500 patients as opposed to the target of 5000). There was, nevertheless, improved survival to hospital admission and improved ROSC with the use of standard-dose epi- nephrine. Observational studies were performed that evalu- ated epinephrine, with conflicting results.114,115