The protein's activity is raised in overweight and obese people and because of this high endothelin-1 activity, small vessels are more prone to constricting, becoming less responsive to blood flow demand and increasing the risk of vascular disease.
The protein's activity is raised in overweight and obese people and because of this high endothelin-1 activity, small vessels are more prone to constricting, becoming less responsive to blood flow demand and increasing the risk of vascular disease.