We acknowledge other limitations of this review. Due to the limited
number of studies reviewed, we were unable to provide information on
the safety of specific types of exercise training (i.e., aerobic vs. resistance
exercise). There was a lack of complete reporting on the exercise training
protocols and considerable variability in the prescription of exercise
training, particularly exercise intensity, and this might act as a potential
confounder. We further acknowledge the potential for attention bias associated
with the exercise training condition. Participants involved in
exercise training were likely monitored more closely and more frequently
by the investigators compared to controls, which could have resulted
in an underestimation of the number of events experienced by
controls. Future studies should ensure similar monitoring of participants
in both control and intervention conditions throughout exercise
training studies to provide the most accurate assessment of the safety
of exercise training in MS.