Certain cholesterol-lowering agents – Cholestyramine, a bile acid sequestrant used for reducing blood cholesterol, binds with acetaminophen thereby preventing it from being absorbed by the body. Cholestyramine reduces the desired pharmacologic effect of paracetamol. If taking these medications together, acetaminophen should be taken at least 1 hour before cholestyramine, or at least 3 to 4 hours after cholestyramine.