a member of a major therapeutic class of oral agents used as
migraine prophylaxis (beta blockers, antidepressants, and
anticonvulsants). Studies were limited to prospective and retrospective
observational studies on adherence and persistence
of migraine prophylaxis and RCTs of the 3 aforementioned
migraine prophylaxis medications. Studies examining use for
headache disorders other than migraine were excluded, as were
editorials/commentaries, reviews, case studies, animal studies,
cost-effectiveness studies, pharmacokinetic studies, and guidelines.
Articles not available in English and studies conducted in
children/adolescents (< 18 years of age), elderly, and pregnant
subpopulations were also omitted.