Endophytic fungi live inside plants, apparently do not cause any harm to their hosts and
may play important roles in defense and growth promotion. Endophytes are
microorganism that lives between living plant cell. Their relationship may vary with plant
from symbiotic to bordening on pathogenic. Endophytes may contribute to their host
plant by producing a plethora of substances that provide protection and ultimately
survival value to the plant. Of all plant species on only a few grass species have had
their complete complement of endophyte studied. As a result the opportunity to find new
and interesting endophyte derived bioactive compound is great. Endophytes have
proved to be a rich source of novel chemistry and biological molecules. The review aim
at endophyte successful isolation methods , media used as well as different as well as
production of secondary metabolites with special emphasis on anticancerous, anti-TB,
antimicrobial, antibiotics along with a huge number of other secondary metabolites for
commercial exploitation in pharmaceutical and medical field. With day to day increasing
demand of drugs plant sources are proving to be able to meet the tremendous demand,
endophytes can serve the purpose of mass scale production of bioactive metabolites to
mitigate the increasing demand and prospect of finding new drugs that may be effective
candidates for treating newly developing diseases in humans, plants, and animals are
immense.