Conclusions: Anatomical and restingstate
functional deficits were observed in
different brain regions, indicating that
anatomical and functional brain abnormalities
are significantly dissociated in the
early course of schizophrenia. The lack of
association of these abnormalities with illness
duration and episode severity suggests
that these anatomical and functional
changes may be early-evolving features of
the illness that are relatively stable early in
the course of illness. The different structural
deficits of regional gray matter observed in
patients with prominent negative symptoms
may provide unique insight into the
early regional neuropathology of this symptom
dimension in schizophrenia.