[0017] The เรเร of the present การประดิษฐ์ can regulate the expression levels of the Per and Bmal genes in anti phase ซึ่งกันและกัน, thereby entraining the expression rhythms of said genes to their normal phases.
The expression levels of the Per and Bmal genes regulated by the inventive เรเร can be evaluated using a given method known to those skilled in the art.
[0018] To perform evaluation in living organisms, a test animal such as mouse, rat, guinea
pig, rabbit, dog, cat, horse, monkey, or human can be used depending on the purpose. A
control group is not treated with a test substance while a test group is treated with a test