Even assuming that some lipid nanoparticles might arrive in the systemic blood circulation, they will be very well tolerated.
Based on their composition they are rather a kind of parenteral nutrition.
In the 1990s in vivo studies showed that intravenously injected lipid nanoparticle suspensionswere verywell tolerated (Weyhers, 1995; Weyhers et al., 1995).