Apart from a few reports; Wu (1995), Snow and Ghaly (2008),etc. in literature, information on the use of water lettuce waste stabilization pond for industrial wastewater treatment and the reuse of the resulting effluent as biofertilizer is still scanty. This study was there fore carried out to assess the efficiency of water lettuce basedpond for the treatment of wastewater from rubber processing factories. The reuse of the treated effluent as liquid biofertilizer wasalso investigated. Water lettuce (Pistia stratiotes Linn) belongs to the family Araceae. A free-floating aquatic herb with thick, succulent leaves, profuse under water stolons and long, white, unbranched fibrous roots that may sometimes attach to the bottom of shallow waters. It reproduces mainly vegetatively by buds and stolons and rarely produces seeds. They are oblong in shape, 6–12 cm long and 5 cm broad, spongy, strongly inflated and softly hairy on both surfaces, the lower surface has conspicuous veins (nerves) radiatingfrom the base of the leaves. It is a common aquatic weed that occursin still waters, ponds and pools or in slow flowing rivers and streamsthroughout West Africa. Aquatic weeds growing in ponds and lakesare beneficial for fish and wildlife. Besides providing food and dis-solved oxygen, aquatic weeds can also trap excessive nutrients anddetoxify chemicals (Masters, 1991).