The assertion that somehow fatty acid oxidation for energy is preferable to glycolysis is one of the latest gimmicks out there as folks following these generally opportunistic gurus increase their fat consumption and reduce protein consumption in search of some "Holy Grail" of metabolism ... or nutritional ketotic nirvana ... to be a fat burning beast ... burn low and slow or fast and furious depending on which guru you follow. Is it true? I'd say the jury is out and there's at least as much evidence out there to support a glucose dominated metabolism, or better yet, IMO, the notion of agnostic mitochondria so long as they are well nourished but not over nourished.
Hopefully in the end, we can sort through some of what is true and that which is woo in this whole realm of mitochondrial dysfunction, insulin resistance, diabetes and all manner of "metabolic derangement". In the context of the electrochemistry involved we can sort through what impact, if any, the macronutrient composition of one's diet and/or its caloric content may have, and other factors like genetics that are at play. To the latter there is ever emerging peer review literature to discuss, but as to the relationship between diet and mitochondrial function, the waters are far more murky. I invite everyone, including detractors, to participate here in the comments as only by discussing these things and being challenged can we endeavor to arrive at the truth to the best that the available scientific evidence allows us.
The assertion that somehow fatty acid oxidation for energy is preferable to glycolysis is one of the latest gimmicks out there as folks following these generally opportunistic gurus increase their fat consumption and reduce protein consumption in search of some "Holy Grail" of metabolism ... or nutritional ketotic nirvana ... to be a fat burning beast ... burn low and slow or fast and furious depending on which guru you follow. Is it true? I'd say the jury is out and there's at least as much evidence out there to support a glucose dominated metabolism, or better yet, IMO, the notion of agnostic mitochondria so long as they are well nourished but not over nourished.
Hopefully in the end, we can sort through some of what is true and that which is woo in this whole realm of mitochondrial dysfunction, insulin resistance, diabetes and all manner of "metabolic derangement". In the context of the electrochemistry involved we can sort through what impact, if any, the macronutrient composition of one's diet and/or its caloric content may have, and other factors like genetics that are at play. To the latter there is ever emerging peer review literature to discuss, but as to the relationship between diet and mitochondrial function, the waters are far more murky. I invite everyone, including detractors, to participate here in the comments as only by discussing these things and being challenged can we endeavor to arrive at the truth to the best that the available scientific evidence allows us.
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