In our previous study,2 the rats with GERD did not
develop laryngeal granuloma in the vocal cord mucosa during
the postsurgical observation period of 20 weeks.
Moreover, in the present study, the rats with only mechanical
injury of the vocal cord mucosa (control group) did not
develop laryngeal granuloma. However, more than 50% of
the rats with both gastric acid reflux and mechanical injury
of the vocal cord mucosa (GERD group) developed laryngeal
granuloma despite experiencing the same type and
degree of injury. These findings indicate that laryngeal