although it is suggested that the therapeutic
effect of MPH is mainly due to the DA transporter blockade .
Some studies have evidenced the DA role on the pre-pubertal maturation
stages in different vertebrate species . It is known that
early exposure to MPH could lead to long-lasting alterations in brain
DA pathways and natural reward systems , which are related to
sexual behavior performance . In this sense, impairment of sexual
behavior performance was demonstrated in adult rats treated with
MPH during adolescence , and alterations on hormonal profile
and spermatogenesis were observed shortly after drug
discontinuation.