The technique involves the injection of substances to stimulate the mesoderm for various biological purposes. Extremely small needles are used to penetrate the interdermal layer of the skin, typically 4 to 6 millimeters. The number of treatments depends on the condition and the duration of the condition. Usuallyone to three treatments are needed. Mesotherapy is effective for a multitude of conditions to stop the pain spasm cycle. A complete physical examination must be done prior to mesotherapy or any other type of therapy.