In this paper we propose a novel engineering approach in
the treatment of neurodegenerative diseases, based on con-
trolled radio frequency (RF) exposure. In recent experi-
ments on mobile phone exposure of transgenic Alzheimer’s
disease (AD) mice, improved cognitive functions were ob-
served, inspiring a possible regression of the disease after
RF treatment. To this end, we define a parallelism between
neuronal and communication systems, defining a conceptual
RF-neuronal interface to exploit the impact of the electro-
magnetic (EM) induced currents on the cellular membrane,
where the biological messages are generated. Preliminary
simulation results confirmed this hypothesis. In a thera-
peutical perspective, controlled RF exposure is expected to
affect the brain activity at networking level where, in AD
patients, broken links between functional areas of the brain
give rise to cognitive and behavioural dysfunctions. A pos-
sible solution is to restore the missing paths enhancing the
neuronal activity by means of controlled RF exposure.