Airway Hyperresponsiveness Was Attenuated by Aerobic Exercise
Airway hyperresponsiveness is a hallmark of asthma. In this study, OVA exposure resulted in a marked increase in AHR for MCh 25 mg/mL (Figure 6A) and 50 mg/mL (Figure 6B), whereas for PBS, 6.25 and 12.5 mg/mL no differences were found (data not shown). Importantly, AE significantly reduced AHR to MCh 25 mg/mL (Figure 6A) and 50 mg/mL (Figure 6B), demonstrating that the anti-inflammatory and the anti-fibrotic effects of AE are followed by reduction in AHR.