inhibitor, their effects are ca 1000-fold lower, as captopril acts in
the nmol/L range with IC ¼ 67.7e97.0%, in contrast with the mmol/L
concentrations of the monomers for which IC ¼ 5.5e81.4%.
Although captopril shows an undoubtedly greater inhibitory capacity,
the purified monomers should not be neglected, as
100 mmol/L solutions decreased ACE activity to the range of 18.6e
35.6%. Furthermore, it is worth noting that these flavanols are
natural compounds present in a wide variety of foods, providing a
source for potential ACE inhibition if bioavailable, without known
adverse side effects. In fact revealed lack of toxicity and sustained the use of
proanthocyanidin-rich extract from grape seeds for various foods.
In contrast, the use of captopril is frequently associated to cough
(the most common adverse effect), rash, and taste disturbances
(metallic or loss of taste), which have been attributed to the unique
sulfhydryl moiety