The aim of this study was to establish the influence of several ethanolic vegetal extracts on in vitro adaptive cell-mediated reactivity in wild (mink, n = 70, silver foxes, n = 22) and domestic (dogs, n = 32) carnivores and compare the responsiveness of these species under physiological (antigen-primed) and pathophysiological (aleutian disase of mink) conditions. Mink and foxes were primed with a 5% SRBC suspension (0.5 and 1 ml respectively), twice, 14 days apart and blood was sampled on days 0 and 14, while untreated dogs were sampled only once.