In the other hand, caffeine, the most widely known compound in coffee. This is risk for heart disease because coffee consumption is likewise connecting with an increase of plasma homocysteine a chance for requisite for heart disease and caffeine is drug. That is influence link to amildcontralnervous system, stimulating to a headache and irritable after quit from drinking behavior but symptoms appear is occurred a few days by Medscape News published an excellent and extensively referenced summary of the potential medical benefits of coffee consumption.