Delivery of a solution containing paramyxovirus exhibited
only short-duration conductance changes characteristic of diffusion
of the virus past andor rapid touching of the nanowire
surface and not specific binding; however, when the solution was
changed to one containing influenza A, conductance changes
consistent with well defined bindingunbinding behavior similar
to that in Fig. 3 were observed. Importantly, these experiments
demonstrate that the antibody-modified nanowire devices exhibit
excellent binding selectivity, which is an important characteristic
for detection of one or more viruses. Although not our
focus, these data also show that the devices are sensitive to single
charged virus particles (including the sign of the charge) as they
diffuse by and sample the nanowire surface, and this capability
could find uses, for example, for charge detection in microfluidic
devices.