In a follow up study, we evaluated the involvement of IAP
protein Survivin during the protective effects of resveratrol against
multiple UVB exposure-mediated damages in SKH-1 hairless
mouse skin. The data from this study demonstrated that topical
pre-treatment of resveratrol (10 lmol in 200 ll acetone per
mouse) resulted in significant inhibition of UVB exposure-mediated
increases in (i) cellular proliferations (Ki-67 immunostaining),
(ii) protein levels of epidermal cyclooxygenase (COX)-2 and
ornithine decarboxylase (ODC), established markers of tumor promotion,
(iii) protein and mRNA levels of Survivin, and (iv) phosphorylation
of Survivin; in the skin of SKH-1 hairless mouse [6].
Resveratrol pre-treatment also resulted in (i) reversal of UVB-mediated
decrease of Smac/DIABLO and (ii) enhancement of UVB-mediated
induction of apoptosis, in mouse skin
In a follow up study, we evaluated the involvement of IAP
protein Survivin during the protective effects of resveratrol against
multiple UVB exposure-mediated damages in SKH-1 hairless
mouse skin. The data from this study demonstrated that topical
pre-treatment of resveratrol (10 lmol in 200 ll acetone per
mouse) resulted in significant inhibition of UVB exposure-mediated
increases in (i) cellular proliferations (Ki-67 immunostaining),
(ii) protein levels of epidermal cyclooxygenase (COX)-2 and
ornithine decarboxylase (ODC), established markers of tumor promotion,
(iii) protein and mRNA levels of Survivin, and (iv) phosphorylation
of Survivin; in the skin of SKH-1 hairless mouse [6].
Resveratrol pre-treatment also resulted in (i) reversal of UVB-mediated
decrease of Smac/DIABLO and (ii) enhancement of UVB-mediated
induction of apoptosis, in mouse skin
การแปล กรุณารอสักครู่..