This study explores the nature of anxiety in asking questions in class from the perspective of 10 Thai students majoring in English at Didyasarin International College, Hatyai University. The data was collected through an in-depth semi-structured qualitative interview format. The interview was adapted from Peng Wang and Randhir Roopchund, as it dealt with coping strategies pertaining to these learners’ anxiety in asking questions in class. This anxiety exerts compound effects on respondents with respect to their mind, body and actual speaking performance. A series of factors contributing to this anxiety are reported by respondents, which can be categorised as 1) personal and interpersonal anxiety; 2) learner beliefs about English language learning; 3) role of instructors; 4) students’ personality; and 5) students’ educational and cultural background. Effective strategies for coping with this anxiety reported by respondents mainly consist of 1) preparation; 2) self-encouragement; 3) peer seeking; 4) relaxation; 5) practice; and 6) ignoring others’ negative evaluations.