Over the past decade, nurses have been part of a movement that reflects perhaps more change than any two decades combined Directions in nursing education in the 1960s established nursing as an applied science. This was the entry of our profession into the age of knowledge. Only in the mid-1990s did it become clear that producing new knowledge was not enough. To affect better patient outcomes, new knowledge must be transformed into clinically useful forms, effectively implemented across the entire care team within a systems context, and measured in terms of meaningful impact on performance and health outcomes. The recently- articulated vision for the future of nursing in the Future of Nursing report (IOM, 2011a) focuses on the convergence of knowledge, quality, and new functions in nursing. The recommendation that nurses lead inter professional teams in improving delivery systems and care brings to the fore the necessity for new competencies, beyond evidence-based practice (EBP), that are requisite as nurses transform healthcare. These competencies focus on utilizing knowledge in clinical decision making and producing research evidence on interventions that promote uptake and use by individual providers and groups of providers.