However, when reviewing these aspects of treatment it needs to
be clarified that, overall, the quality of the literature is quite limited.
There remain multiple methodological issues which have been
repeatedly pointed out in previous reviews [5,14,16]. These include
a lack of detail regarding such items as effects of age and sex, the
details of the alcohol-use and its severity and chronicity, and if there
are other comorbid conditions. These qualifications regarding the
overall quality of the data should be recognized when considering the
findings that are available