Results
Being obese or underweight at diagnosis and for 50% of the time between end of induction and
start of maintenance therapy resulted in inferior EFS (hazard ratios, 1.43 and 2.30, respectively;
global P .001). Normalization of weight during that period resulted in mitigation of this risk
comparable to never being obese or underweight. Obese or underweight status at start of each
treatment course was significantly associated with specific patterns of TRT.