In McFarlane’s study, 30 patients undergoing major
hepatobiliary or pancreatic surgery were randomly
allocated to receive either sodium chloride 0.9% or
Plasma-lyte at 15 mL/kg/h.
12
Patients receiving sodium
chloride 0.9% had significantly increased chloride
concentration (p < 0.01), decreased standard bicarbonate
concentration (p < 0.01) and increased base deficit (p <
0.01) compared to those receiving Plasma-lyte.