In this study, a method based on solid-phase extraction (SPE) and liquid chromatography–tandem mass spectrometry (LC–MS–MS) has beendeveloped and validated for the determination of eight sweeteners (saccharin, cyclamate, aspartame,acesulfame, neohesperidin dihydrochalcone, sucralose, stevioside and glycyrrhizic acid) in river waterand wastewater