There are more than 100 different types of cancer. Every cancer and every individual is unique. The symptoms and signs of cancer depend on the size and location of the cancer as well as the presence or absence of metastasis. Symptoms and signs such as fever, pain, fatigue, skin changes (redness, sores that won't heal, jaundice, darkening), and unintended weight loss or weight gain are not unique to cancer, but they often occur with cancer. More potential cancer signs and symptoms include the presence of a lump, difficulty swallowing, changes or difficulties with bowel or bladder function, persistent cough, hoarseness, and unexplained bleeding or discharge.