Local risk factors include:
A. Dentoalveolar surgery, including, but not limited to
1. Extractions
2. Dental implant placement
3. Periapical surgery
4. Periodontal surgery involving osseous injury
In the original Position Paper, local factors such as dentoalveolar procedures, local
anatomic structures, e.g., tori, and concomitant dental disease were hypothesized to
increase the risk for BRONJ in the setting of IV bisphosphonate exposure.
Patients
receiving IV bisphosphonates and undergoing dentoalveolar surgery are at least seven
times more likely to develop BRONJ than patients who are not having dentoalveolar
surgery.In the setting of IV bisphosphonate exposure, four studies reported that
dentoalveolar procedures or concomitant dental disease increased the risk for BRONJ
between 5.3 (odds ratio) to 21 (relative risk).In other words, cancer patients
treated with IV bisphosphonates who undergo dentoalveolar procedures have a 5 to 21-
fold increased risk for BRONJ than cancer patients treated with IV bisphosphonates who
do not undergo dentoalveolar procedures.
Local risk factors include:A. Dentoalveolar surgery, including, but not limited to1. Extractions2. Dental implant placement3. Periapical surgery4. Periodontal surgery involving osseous injuryIn the original Position Paper, local factors such as dentoalveolar procedures, localanatomic structures, e.g., tori, and concomitant dental disease were hypothesized toincrease the risk for BRONJ in the setting of IV bisphosphonate exposure. Patientsreceiving IV bisphosphonates and undergoing dentoalveolar surgery are at least seven times more likely to develop BRONJ than patients who are not having dentoalveolarsurgery.In the setting of IV bisphosphonate exposure, four studies reported thatdentoalveolar procedures or concomitant dental disease increased the risk for BRONJbetween 5.3 (odds ratio) to 21 (relative risk).In other words, cancer patientstreated with IV bisphosphonates who undergo dentoalveolar procedures have a 5 to 21-fold increased risk for BRONJ than cancer patients treated with IV bisphosphonates whodo not undergo dentoalveolar procedures.
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