In vivo SPME analysis was also used for profiling skin emissions [48–50]. It was demonstrated that utilization of the extraction phase in thin-film format allows metabolic profiling, which permits different areas of the body to be distinguished [50] as well as changes in clinical conditions of the skin to be monitored [49]. The non-invasive nature of the method and its simplicity are features that showcase the strong potential of the approach in the medical diagnostic area.