Daily weaning trials and sedation holidays: When the decision is made to intubate a patient, a strategy to liberate the patient from mechanical ventilation must also be considered. Daily weaning trials and sedation holidays have been repeatedly described and validated as strategies that limit the time of mechanical ventilation. As the risk of VAP is related to the duration of mechanical ventilation, limiting this duration makes physiologic sense though no randomized trials have shown a benefit with regards to reduction in VAP rates.