Inflammation is a very complex pathophysiological process involving a variety of biomoleucles responsible for causing it such as leucocytes, macrophages, mast cells, platelets and lymphocytes by releasing eicosanoids and nitric oxide. Pro inflammatory cytokines such as TNF-α and IL-1β are also responsible for various inflammatory conditions. Many species of the genus Clerodendrum showed potent anti-inflammatory activity. C. phlomidis was reported for significantly decreasing paw oedemas induced by carrageenan in rats at a dose of 1g/kg (Surendrakumar 1988). Similarly C. petasites was reported to show moderate anti-inflammatory activity in the acute phase of inflammation in rats. The ED50 values of the experiment were reported to be 2.34 mg/ear and 420.41 mg/kg in rats (Panthong et al. 2003), it has been suggested by the authors that the anti-inflammatory activity of the plant extract could be due to the inhibition of prostaglandin synthesis by the extract.