Amino acid supplementation has been the backbone of poultry nutrition. This well-known fact is demonstrated with methionine being the first limiting amino acid for broilers raised on a corn-soy based diet (Burley, 2012). The utilization of synthetic methionine and improving its bioavailability in feed has played a key role in constantly improving poultry performance. There are two main synthetic methionine varieties produced chemically to be used in poultry viz., DL-methionine powder form (DLM, 99%), and 2-hydroxy-4-(methylthio) butyric acid liquid form (HMB, 88%). Recently a third variety derived from biomass has been introduced. The relative bio-efficacy of DLM and HMB differs as shown in laying hens. A study by Danner and Bessei (2002) demonstrated the efficacy of HMB relative to DLM, which found to be 69% (feed conversion ratio, FCR) and 67% (daily egg mass) lower than DLM. Another study by Meirelles et al. (2003) compared DL-methionine hydroxy analog-free acid (MHA-FA) to DLM supplementation and demonstrated the latter to be a better performing feed additive for methionine supplementation. Recently, a direct relation in the relative bioavailability of MHA-FA, a poly herbal ingredient (PHI) with DLM was proposed as a feed additive The PHI claims to contain a blend of dipeptides and oligopeptides of methionine as well as certain intermediates of the same amino acid. The study states a 58% and 4.5% relative bioavailability for MHA-FA and PHI to that of DLM on a product basis respectively (Sangali et al., 2014).