In addition, cocoa extracts can dose-dependently
inhibit activity of digestive enzymes including secreted phospholipase
A2 (PLA2, IC50 b20 μg/ml) in vitro [27]. In the present study, we
investigated the preventative effects of a long-term dietary cocoa
powder supplementation on AT inflammation though the regulation
of pro-inflammatory gene expression, eicosanoid metabolism and
metabolic endotoxemia in HF-fed C57BL/6J mice.