Completely ablated tumor after 36% NaCl pretreatment. This gross pathologic specimen is a bivalved section of a 5.5-cm dog tumor (white central regions). In addition to complete ablation of the entire tumor (as subsequently documented by staining for mitochondrial enzyme function), there is marked extension of thermal damage beyond the tumor margin. This includes liquefied fat (black arrows) as well as a wide rim of hyperemia (white arrows) at a minimum of 1 cm from the peripheral margin of the tumor..